Optimizing the Yield of a Pure Enantiomer by Integrating Chiral SMB Chromatography and Racemization. Part 2: Theory

We address the purification of target enantiomer a chiral compound from its racemic mixture, through simulated moving bed (SMB) chromatography either as standalone or combined with recycle and racemization undesired enantiomer. carry out comparative assessment two processes focus on role kinetics, effect selectivity stationary phase, upstream symmetric synthesis racemate. The analysis is general thanks to methods adopted for optimal design integrated process (with racemization) sizing SMB unit, well use four generalized Langmuir adsorption isotherms. In this way, we determine quantitative criteria that show outperforms when performance catalyst phase poor feed inexpensive.